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The treatment of SCCA has evolved over the last 5 decades from a mutilating radical surgical treatment with a modest survival probability to an individualized radiation treatment with or without concurrent chemotherapy with good survival outcome and acceptable morbidity. Sphincter preservation is one of the main objectives of the surgical treatment of rectal cancer. Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial. Background: With the increased usage of neoadjuvant chemoradiotherapy, improved surgical technique and stapling devices, sphincter-preserving resection has become more frequent for patients with rectal cancer. If the resection margin is too close or involved, a wider excision is performed, if possible. In most of those studies, the local recurrence rate of patients with pCR was zero [ 14—18 , 21 , 22 , 25 , 26 , 28 ].
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